Big Hand has been toned done a bit from previous editions, but the flip side is there are now a lot of players who can take it as a normal skill.
Listing of all the mutation skills in the game and an explanation on their best uses as well as which players to bear in mind to select them on.
Extra Arms has had a boost to its abilities to change it from a skill that was never taken into one that is invaluable to certain types of players.
Horns gives you a strength bonus when blitzing. Read this for best uses and players that it is an ideal skill for.
Prehensile Tail makes it harder for opposing players to get away, making it a useful addition to anyone player developing as a marking specialist.
Tentacles is a skill taken by very strong players with Mutation access. The ability to prevent weak but agile opponents from moving is very useful.